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論文紹介



・リファレンス


・DNA中Gh、Sp修復酵素
　Nucleic Acids Research, 2001, Vol.29, No.9 1967-1974
　Repair of hydantoins, one electron oxidation product of 8-oxoguanine, by DNA glycosylases of Esherichia coli

・DNAのlagging鎖とleading鎖、どちらに8-OGが取り込まれるか
　Mol Gen Genet, 2001, Vol.264 836-841
　Miscoding and misincorporation of 8-oxo-guanine during leading and lagging strand synthesis in Esherichia coli

・MutYによるDNAのGC->CG変異抑制
　Nucleic Acids Research, 1998, Vol.26, No.20 4669-4675
　Escherichia coli MutY protein has a guanine-DNA glycosylase
　　that acts on 7,8-dihydro-8-oxoguanine:guanine mispair to prevent spontaneous G:C -> C:G transversions

・1O2によるDNA損傷修復
　Nucleic Acids Research, 2001, Vol.29, No.13 2899-2903
　DNA repair and sequence context affect 1O2-induced mutagenesis in bacteria

・8-OGと相補的な塩基は？
　Nature, 1991, Vol.349 431-434
　Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

・MutS過剰発現によるG:C->T:A変異抑制
　Journal of Bacteriology, 2000, Vol.182, No.17 5025-5028
　Reduction of GC->TA Transversion Mutation by Overexpression of MutS in Esherichia coli K-12

・DNA酸化傷害における活性酸素と鉄の関係
　The Journal of Biological Chemistry, 1999, Vol.274, No.49 34832-34837
　Role of Iron and Superoxide for Generation of Hydroxyl Radical, Oxidative DNA Lesions, and Mutagenesis
　　in Esherichia coli

・哺乳類細胞分画による8-OG修復活性
　Carcinogenesis, 2000, Vol.21, No.6 1135-1141
　Comparative repair of the endogenous lesions 8-oxo-7,8-dihydroguanine(8-oxoG), uracil and abasic site
　　by mammalian cell extracts: 8-oxoG is poorly repaired by human cell extracts

・hOGH1：ヒト8-OG DNA glycosylase
　The EMBO Journal, 1997, Vol.16, No.20 6314-6322
　Opposite base-dependent reactions of a human base excision repair enzyme
　　 on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites

・γ線による突然変異誘発とMutM、MutY
　Mutation Research, 2000, Vol.461 189-195
　The influence of combined Fpg- and MutY-deficiency on the spontaneous
　　 and γ-radiation-induced mutation spectrum in the lacZα gene of M13mp10

・8-OG酸化産物とポリメラーゼ反応
　Nucleic Acids Research, 1999, Vol.27, No.2 496-502
　Insertion of dGMP and dAMP during in vitro DNA synthesis opposite an
　　 oxidized form of 7,8-dihydro-8-oxoguanine

・MutY glycosylase活性と塩濃度
　Nucleic Acids Research, 2000, Vol.28, No.24 4912-4918
　Adenine excisional repair function of MYH protein
　　　　 on the adenine:8-hydroxyguanine base pair in double-stranded DNA

・10-18molオーダーAPサイト超高感度蛍光検出試薬
　Nucleic Acids Research, 1999, Vol.27, No.5 1316-1322
　Novel non-isotopic detection of MutY enzyme-recognized mismatches in DNA
　　　　 via ultrasensitive detection of aldehydes

・レビュー：核とミトコンドリアにおける酸化傷害修復機構
　The Journal of Biological Chemistry, 1997, Vol.272, No.41 25409-25412
　Repair of Oxidative Damage to Nuclear and Mitochondrial DNA in Mammalian Cells

・Guanineの反対に取り込まれる2-oxodATPの変異原性
　Nucleic Acids Research, 2000, Vol.28, No.7 1640-1646
　2-Hydroxy-dATP is incorporated opposite G by Escherichia coli DNA polymerase III resulting in high mutagenicity

・APサイトアナログとDNA glycosylaseとの相互作用
　The Journal of Biological Chemistry, 1998, Vol.273, No.15 8592-8597
　Specific Binding of a Designed Pyrrolidine Abasic Site Analog to Multiple DNA Glycosylases

・ヒトHSP70によるAP endonucleaseの活性化
　The Journal of Biological Chemistry, 2001, Vol.276, No.12 9532-9536
　Heat Shock Protein 70 Binds to Human Apurinic/Apyrimidinic Endonuclease
　　　　　 and Stimulates Endonuclease Activity at Abasic Sites

・MutYのA:AOに対する活性とMutMのAP:GOに対する活性阻害
　Biochemistry, 1992, Vol.31, No.45 10964-10968
　A Repair System for 8-Oxo-7,8-dihydrodeoxyguanine

・RNA前駆体GTPの酸化物8-oxoGTPの代謝
　Biochemistry, 1999, Vol.38, No.12 3610-3614
　Metabolic Fate of Oxidized Guanine Ribonucleotides in Mammalian Cells

・MutYのThermolysin処理によるC末ドメイン除去
　Biochemistry, 1996, Vol.35, No.51 16665-16671
　Specific Recognition of A/G and A/7,8-Dihydro-8-oxoguanine(8-oxoG) Mismatches
　　by Escherichia coli MutY: Removal of the C-Terminal Domain Preferentially Affects A/8-oxoG Recognition

・hMYHの2-OAとの反応とmRNAバリアント
　Nucleic Acids Research, 2000, Vol.28, No.6 1355-1364
　Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA
　　　 and detection of multiple forms of hMYH located in nuclei and mitchondria

・Helix-Hairpin-Helixモチーフによる傷害塩基の認識機構
　Biochemistry, 1997, Vol.36, No.16 4713-4717
　DNA Polymerase β in Abasic Site Repair: A Structurally Conseved Helix-Hairpin-Helix Motif in Lesion Detection by Base Excision Repair Enzymes

・MutYのglycosylase活性にLys142は不必要
　Biochemistry, 1999, Vol.38, No.47 15417-15424
　Formation of a Schiff Base Intermeiate Is Not Required for the Adenine Glycosylase Activity of Escherichia coli MutY

・APサイトDNAの熱力学的安定性
　Biochemistry, 1998, Vol.37, No.20 7321-7327
　Thermodynamic Consequences of an Abasic Lesion in Duplex DNA Are Strongly Dependent on Base Sequence

・AP lyase反応機構とNaBH4
　Biochemistry, 2001, Vol.40, No.2 561-568
　The Reaction Mechanism of DNA Glycosylase / AP Lyases at Abasic Sites

・Phosphorylaseは酸化障害RNAと結合
　Biochemistry, 2001, Vol.40, No.33 9977-9982
　Specific Binding of 8-Oxoguanine-Containing RNA to Polynucleotide Phosphorylase Protein

・RIPsはssDNA glycosylase/AP lyase活性を持つ
　The Journal of Biological Chemistry, 1998, Vol.273, No.27 17216-17220
　A New Class of DNA Glycosylase / Apurinic / Apyrimidinic Lyases That Act on Specific Adenines in Single-stranded DNA

・活性酸素種と鉄
　The Journal of Biological Chemistry, 1997, Vol.272, No.31 19095-19098
　Formation, Prevention, and Repair of DNA Damage by Iron / Hydrogen Peroxide

・ミトコンドリア内塩基除去修復におけるPolγのdRP lyase活性
　Proc. Natl. Acad. Sci. USA, 1998, Vol.95, 12244-12248
　Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase γ and its role in mitochondrial base excision repair in vitro

・MutYとKd＜1pMで結合する遷移状態アナログ
　J. Am. Chem. Soc., 1997, Vol.119, No.33 7865-7866
　Unusually Strong Binding of a Designed Transition-State Analog to a Base-Excision DNA Repair Protein

・非極性adenineアナログとMutYの基質認識
　Org. Lett., 2000, Vol.2, No.9 1341-1344
　Recognition of the Nonpolar Base 4-Methylindole in DNA by the DNA Repair Adenine Glycosylase MutY

・レビュー：塩基除去修復
　Chem. Rev., 1998, Vol.98, No.3 1221-1261
　Chemistry of Glycosylases and Endonucleases Involved in Base-Excision Repair

・8-OG酸化産物とMutYの架橋形成
　J. Am. Chem. Soc., 1999, Vol.121, No.42 9901-9902
　Mechanism-Based DNA-Protein Cross-Linking of MutY via Oxidation of 8-Oxoguanosine

・8-OGの1電子酸化産物spiroiminodihydantoinの同定
　Org. Lett., 2000, Vol.2, No.5 613-616
　Characterization of Spiroiminodihydantoin as a Product of One-Electron Oxidation of 8-Oxo-7,8-dihydroguanosine

・DNA ligaseのAP lyase活性
　The Journal of Biological Chemistry, 1998, Vol.273, No.14 7888-7893
　The Action of DNA Ligase at Abasic Sites in DNA

・ストップトフローによるFpg酵素反応解析
　Biochemistry, 2002, Vol.41, No.5 1520-1528
　Stopped-Flow Kinetics Studies of the Interaction between Escherichia coli Fpg Protein and DNA Substrates

・hOGG1のAPE1による活性化機構
　Nucleic Acids Research, 2001, Vol.29, No.2 430-438
　Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repair

・へリックスの安定化予測とタンパク質の安定性
　Folding & Design, 1995/1996, Vol.1, No.1 29-34
　Stabilization of proteins by rational design of α-helix stability using helix/coil transition theory



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