メイン


論文紹介



リファレンス


DNA中Gh、Sp修復酵素
 Nucleic Acids Research, 2001, Vol.29, No.9 1967-1974
 Repair of hydantoins, one electron oxidation product of 8-oxoguanine, by DNA glycosylases of Esherichia coli

DNAのlagging鎖とleading鎖、どちらに8-OGが取り込まれるか
 Mol Gen Genet, 2001, Vol.264 836-841
 Miscoding and misincorporation of 8-oxo-guanine during leading and lagging strand synthesis in Esherichia coli

MutYによるDNAのGC->CG変異抑制
 Nucleic Acids Research, 1998, Vol.26, No.20 4669-4675
 Escherichia coli MutY protein has a guanine-DNA glycosylase
  that acts on 7,8-dihydro-8-oxoguanine:guanine mispair to prevent spontaneous G:C -> C:G transversions

1O2によるDNA損傷修復
 Nucleic Acids Research, 2001, Vol.29, No.13 2899-2903
 DNA repair and sequence context affect 1O2-induced mutagenesis in bacteria

8-OGと相補的な塩基は?
 Nature, 1991, Vol.349 431-434
 Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

MutS過剰発現によるG:C->T:A変異抑制
 Journal of Bacteriology, 2000, Vol.182, No.17 5025-5028
 Reduction of GC->TA Transversion Mutation by Overexpression of MutS in Esherichia coli K-12

DNA酸化傷害における活性酸素と鉄の関係
 The Journal of Biological Chemistry, 1999, Vol.274, No.49 34832-34837
 Role of Iron and Superoxide for Generation of Hydroxyl Radical, Oxidative DNA Lesions, and Mutagenesis
  in Esherichia coli

哺乳類細胞分画による8-OG修復活性
 Carcinogenesis, 2000, Vol.21, No.6 1135-1141
 Comparative repair of the endogenous lesions 8-oxo-7,8-dihydroguanine(8-oxoG), uracil and abasic site
  by mammalian cell extracts: 8-oxoG is poorly repaired by human cell extracts

hOGH1:ヒト8-OG DNA glycosylase
 The EMBO Journal, 1997, Vol.16, No.20 6314-6322
 Opposite base-dependent reactions of a human base excision repair enzyme
   on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites

γ線による突然変異誘発とMutM、MutY
 Mutation Research, 2000, Vol.461 189-195
 The influence of combined Fpg- and MutY-deficiency on the spontaneous
   and γ-radiation-induced mutation spectrum in the lacZα gene of M13mp10

8-OG酸化産物とポリメラーゼ反応
 Nucleic Acids Research, 1999, Vol.27, No.2 496-502
 Insertion of dGMP and dAMP during in vitro DNA synthesis opposite an
   oxidized form of 7,8-dihydro-8-oxoguanine

MutY glycosylase活性と塩濃度
 Nucleic Acids Research, 2000, Vol.28, No.24 4912-4918
 Adenine excisional repair function of MYH protein
     on the adenine:8-hydroxyguanine base pair in double-stranded DNA

10-18molオーダーAPサイト超高感度蛍光検出試薬
 Nucleic Acids Research, 1999, Vol.27, No.5 1316-1322
 Novel non-isotopic detection of MutY enzyme-recognized mismatches in DNA
     via ultrasensitive detection of aldehydes

レビュー:核とミトコンドリアにおける酸化傷害修復機構
 The Journal of Biological Chemistry, 1997, Vol.272, No.41 25409-25412
 Repair of Oxidative Damage to Nuclear and Mitochondrial DNA in Mammalian Cells

Guanineの反対に取り込まれる2-oxodATPの変異原性
 Nucleic Acids Research, 2000, Vol.28, No.7 1640-1646
 2-Hydroxy-dATP is incorporated opposite G by Escherichia coli DNA polymerase III resulting in high mutagenicity

APサイトアナログとDNA glycosylaseとの相互作用
 The Journal of Biological Chemistry, 1998, Vol.273, No.15 8592-8597
 Specific Binding of a Designed Pyrrolidine Abasic Site Analog to Multiple DNA Glycosylases

ヒトHSP70によるAP endonucleaseの活性化
 The Journal of Biological Chemistry, 2001, Vol.276, No.12 9532-9536
 Heat Shock Protein 70 Binds to Human Apurinic/Apyrimidinic Endonuclease
      and Stimulates Endonuclease Activity at Abasic Sites

MutYのA:AOに対する活性とMutMのAP:GOに対する活性阻害
 Biochemistry, 1992, Vol.31, No.45 10964-10968
 A Repair System for 8-Oxo-7,8-dihydrodeoxyguanine

RNA前駆体GTPの酸化物8-oxoGTPの代謝
 Biochemistry, 1999, Vol.38, No.12 3610-3614
 Metabolic Fate of Oxidized Guanine Ribonucleotides in Mammalian Cells

MutYのThermolysin処理によるC末ドメイン除去
 Biochemistry, 1996, Vol.35, No.51 16665-16671
 Specific Recognition of A/G and A/7,8-Dihydro-8-oxoguanine(8-oxoG) Mismatches
  by Escherichia coli MutY: Removal of the C-Terminal Domain Preferentially Affects A/8-oxoG Recognition

hMYHの2-OAとの反応とmRNAバリアント
 Nucleic Acids Research, 2000, Vol.28, No.6 1355-1364
 Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA
    and detection of multiple forms of hMYH located in nuclei and mitchondria

Helix-Hairpin-Helixモチーフによる傷害塩基の認識機構
 Biochemistry, 1997, Vol.36, No.16 4713-4717
 DNA Polymerase β in Abasic Site Repair: A Structurally Conseved Helix-Hairpin-Helix Motif in Lesion Detection by Base Excision Repair Enzymes

MutYのglycosylase活性にLys142は不必要
 Biochemistry, 1999, Vol.38, No.47 15417-15424
 Formation of a Schiff Base Intermeiate Is Not Required for the Adenine Glycosylase Activity of Escherichia coli MutY

APサイトDNAの熱力学的安定性
 Biochemistry, 1998, Vol.37, No.20 7321-7327
 Thermodynamic Consequences of an Abasic Lesion in Duplex DNA Are Strongly Dependent on Base Sequence

AP lyase反応機構とNaBH4
 Biochemistry, 2001, Vol.40, No.2 561-568
 The Reaction Mechanism of DNA Glycosylase / AP Lyases at Abasic Sites

Phosphorylaseは酸化障害RNAと結合
 Biochemistry, 2001, Vol.40, No.33 9977-9982
 Specific Binding of 8-Oxoguanine-Containing RNA to Polynucleotide Phosphorylase Protein

RIPsはssDNA glycosylase/AP lyase活性を持つ
 The Journal of Biological Chemistry, 1998, Vol.273, No.27 17216-17220
 A New Class of DNA Glycosylase / Apurinic / Apyrimidinic Lyases That Act on Specific Adenines in Single-stranded DNA

活性酸素種と鉄
 The Journal of Biological Chemistry, 1997, Vol.272, No.31 19095-19098
 Formation, Prevention, and Repair of DNA Damage by Iron / Hydrogen Peroxide

ミトコンドリア内塩基除去修復におけるPolγのdRP lyase活性
 Proc. Natl. Acad. Sci. USA, 1998, Vol.95, 12244-12248
 Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase γ and its role in mitochondrial base excision repair in vitro

MutYとKd<1pMで結合する遷移状態アナログ
 J. Am. Chem. Soc., 1997, Vol.119, No.33 7865-7866
 Unusually Strong Binding of a Designed Transition-State Analog to a Base-Excision DNA Repair Protein

非極性adenineアナログとMutYの基質認識
 Org. Lett., 2000, Vol.2, No.9 1341-1344
 Recognition of the Nonpolar Base 4-Methylindole in DNA by the DNA Repair Adenine Glycosylase MutY

レビュー:塩基除去修復
 Chem. Rev., 1998, Vol.98, No.3 1221-1261
 Chemistry of Glycosylases and Endonucleases Involved in Base-Excision Repair

8-OG酸化産物とMutYの架橋形成
 J. Am. Chem. Soc., 1999, Vol.121, No.42 9901-9902
 Mechanism-Based DNA-Protein Cross-Linking of MutY via Oxidation of 8-Oxoguanosine

8-OGの1電子酸化産物spiroiminodihydantoinの同定
 Org. Lett., 2000, Vol.2, No.5 613-616
 Characterization of Spiroiminodihydantoin as a Product of One-Electron Oxidation of 8-Oxo-7,8-dihydroguanosine

DNA ligaseのAP lyase活性
 The Journal of Biological Chemistry, 1998, Vol.273, No.14 7888-7893
 The Action of DNA Ligase at Abasic Sites in DNA

ストップトフローによるFpg酵素反応解析
 Biochemistry, 2002, Vol.41, No.5 1520-1528
 Stopped-Flow Kinetics Studies of the Interaction between Escherichia coli Fpg Protein and DNA Substrates

hOGG1のAPE1による活性化機構
 Nucleic Acids Research, 2001, Vol.29, No.2 430-438
 Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repair

へリックスの安定化予測とタンパク質の安定性
 Folding & Design, 1995/1996, Vol.1, No.1 29-34
 Stabilization of proteins by rational design of α-helix stability using helix/coil transition theory




カテゴリー内記事一覧